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EN ─Y─ BA┼ARI AZ─M KONULU MOT─VASYON F─LMLER─ ─├─N TIKLAYIN.

The findings of these studies are summarized in the following table. (Peak plasma concentration) (Extent of systemic exposure) (500 mg every 8 hrs) (400 mg once daily) The changes in plasma levels were within the range of plasma levels achieved in adequate and well-controlled clinical trials. The mechanism of these interactions has been evaluated in in vitro, in situand in vivo animal models. These studies indicate that ketoconazole or erythromycin co-administration enhances fexofenadine gastrointestinal absorption. This observed increase in the bioavailability of fexofenadine may be due to transport-related effects, such as p-glycoprotein. In vivo animal studies also suggest that in addition to enhancing absorption, ketoconazole decreases fexofenadine gastrointestinal secretion, while erythromycin may also decrease biliary excretion.

This exhibition is supported in part by The Japan Foundation and the Dedalus Foundation, Inc.]